President Biden has finalized deals to buy 200 million more COVID-19 vaccine doses from Pfizer and Moderna by the end of July, increasing the likelihood of delivering on his promise to have all Americans inoculated by mid-summer.

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Additionally, Biden said, Pfizer and Moderna have agreed to expedite the delivery of 100 million doses each by a month — moving them up to May instead of June.

China refused to give raw COVID data to WHO, team member says
The team investigating the origin of the coronavirus outbreak was only provided with a summary, a WHO investigator says.
China refused to give raw data on early COVID-19 cases to a World Health Organization-led team probing the origins of the pandemic, one of the team’s investigators has said.

The team had requested raw patient data on 174 cases that China had identified from the early phase of the outbreak in the city of Wuhan in December 2019, as well as other cases, but were only provided with a summary, said Dominic Dwyer, an Australian infectious diseases expert who is a member of the team.

Such raw data is known as “line listings”, he said, and would typically be anonymised but contain details such as what questions were asked of individual patients, their responses and how their responses were analysed.

“That’s standard practice for an outbreak investigation,” he told the news agency Reuters on Saturday via video call from Sydney, where he is currently undergoing quarantine.

He said that gaining access to the raw data was especially important since only half of the 174 cases had exposure to the Huanan market, the now-shuttered wholesale seafood centre in Wuhan where the virus was initially detected.

“That’s why we’ve persisted to ask for that,” Dwyer said. “Why that doesn’t happen, I couldn’t comment. Whether it’s political or time or it’s difficult … But whether there are any other reasons why the data isn’t available, I don’t know. One would only speculate.”

The four-week WHO mission to China to uncover the origins of the coronavirus wrapped up earlier this week with no conclusive findings.

While the Chinese authorities provided a lot of material, Dwyer said the issue of access to the raw patient data would be mentioned in the team’s final report.

“The WHO people certainly felt that they had received much much more data than they had ever received in the previous year. So that in itself is an advance,” he said.

Meanwhile, on Saturday, another WHO expert voiced frustration over the lack of access to raw data saying more was needed to detect possible early COVID-19 cases.

“We want more data. We have asked for more data,” Peter Ben Embarek, who headed WHO’s mission to Wuhan, told the AFP news agency.

A summary of the team’s findings could be released as early as next week, the WHO said on Friday.

The probe had been plagued by delay, concern over access and bickering between Beijing and Washington, which accused China of hiding the extent of the initial outbreak and criticised the terms of the visit, under which Chinese experts conducted the first phase of research.

The team, which arrived in China in January, was limited to visits organised by their Chinese hosts and prevented from contact with community members, due to health restrictions. The first two weeks were spent in hotel quarantine.

China’s refusal to hand over raw data on the early COVID-19 cases was reported earlier by The Wall Street Journal and The New York Times on Friday.

The Chinese foreign ministry did not immediately reply to a request for comment but Beijing has previously defended its transparency in handling the outbreak and its cooperation with the WHO mission.

Dwyer said the work within the WHO team was harmonious but that there were “arguments” at times with their Chinese counterparts over the interpretation and significance of the data, which he described as “natural” in such probes.

“We might be having a talk about cold chain and they might be more firm about what the data shows than what we might have been, but that’s natural. Whether there’s political pressure to have different opinions, I don’t know. There may well be, but it’s hard to know.”

Cold chain refers to the transport and trade of frozen food.

Peter Daszak, a zoologist, and another member of the WHO mission, however, tweeted on Saturday that he had a different experience as the lead of the mission’s animal and environment working group.

“I found trust & openness w/ my China counterparts. We DID get access to critical new data throughout. We DID increase our understanding of likely spillover pathways,” he said in response to The New York Times piece.

The Bottom Line

So here’s the short version: no sign of ADE during the preclinical animal studies. No sign during the human clinical trials. No sign during the initial vaccine rollouts into the population. And (so far) no sign of ADE even with the variant strains in different parts of the world. We have things to worry about in this pandemic, but as far as I can tell today, antibody-dependent enhancement does not seem to be one of them. I understand why people would worry about it, and want to avoid it. But if you’re coming across reports that say that it’s a real problem right now and that you should avoid getting vaccinated because of it, well, I just don’t see it. Some of that is well-intentioned caution, and some of it is probably flat-out anti-vaccine scaremongering. Anyone with different data or different impressions, well, that’s why the comments are open around here!