There was a recent article in Money magazine about Skybus and their business model should work out fine. They have a unique way of looking at the industry. In a way I think I'd prefer to maybe pay equal or more for a Skybus ticket if it keeps me happy and saves me time.
There model is keep cost low ie no call center. No connecting flights, you can't loose luggage if there are not connections. Pay as you go. Why should I get charged for your checked baggage? Fast service smaller airports mean less people and less security to worry about.
Only time will tell if they can succeed but I hope they do.