Get a couple of these:
http://www.pac-safe.com/www/index.ph...n=detail&id=48
When I travel, I lock my camera bag (which comes with a sewn-in lock, and locking zippers) to the bed frame. I then drape the pac-safe over it, lock it to the bed-frame as well. The laptop gets locked up as well. The only problem I have is if the maids try and vacuum around where the bag is locked up.