My answer before Sept. 11 would have been no; as others have pointed out, hijackers have traditionally (!) relied upon their captives as human currency to be exchanged for the release of political prisoners, etc. The comparatively few deaths that had resulted were either murders to show the terrorists were serious or apparent accidents as where a plane ran out of fuel.

Now, the "rules" appear to have changed. What was unthinkable before has now become our new reality. With that in mind, you bet I would fight. With the kinds of weapons that could realistically be smuggled on board, a concerted attack by passengers should be sufficient to overwhelm the hijackers, though perhaps at the cost of the loss of the aircraft.