Well, yes, seriously. Pretty clear: is there any preference for one or the other points of origin for lower fees and taxes and for better points and miles accrual? Yes I recognize that might be a complex question.
Also, as mentioned, there exists a thread, (to which I've contributed), giving GCM itineraries showing maximum miles various members had constructed. They were mostly 3 continent fares. Now that miles aren't the only factor if one is interested in achieving status or stockpiling miles, that thread is obsolete. Also relevant is the airline you are crediting to. For American, one would prioritize AY, QR, and JL internationally and AS for North America. That might vary for other airlines' members. Maybe the data most valuable to people planning would come from those who've completed their trips and can break down the activity.