Hello there.
First off, hopefully flying 2X weekly you have garned some status on the airline carrying you across the pond. That way you can secure an exit row, or maybe even an u'grade.
Besides that, my best advice is to sleep. Have some red wine as soon as you get aboard and served and you will drift asleep.
My wife & I had a 40+ all in hour journey from Bali to Chicago this past year and a combination of sleeping, and the luck of getting an exit row on the MH flight from KUL-LAX made it seem like nothing at all. Funny enough, the last leg of the flight, LAX-ORD red-eye was the worst!!
Enjoy the trip!!
~A