A FlyerTalk Posting Legend
Join Date: Sep 2009
Location: Minneapolis: DL DM charter 2.3MM
Programs: A3*Gold, SPG Plat, HyattDiamond, MarriottPP, LHW exAccess, ICI, Raffles Amb, NW PE MM, TWA Gold MM
Posts: 100,417
With separate tickets, you risk losing the value of the ticket if your flight is rescheduled, cancelled, or delayed and if you must pay to check luggage, you pay separately on each ticket (with few exceptions).
Be sure that you're eligible (documents, passport/visa, COVID-19 requirements) to transit at any connecting point (on the same ticket) and that you're eligible to enter the country at every destination airport if you use separate tickets.