since Jan 2015 I've logged 420 flight segments, of which 65 have been redeyes (57 as part of Seattle/LA-to-DC travel) ... 19 nonstops on AS/VX/AA, but the advantage of flying DL is a lot of options via JFK/DTW/ATL (I scrupulously avoid the short MSP redeyes from the west coast; only three in that time)

a window seat is essential so I can lean against the sidewall, and my routine is generally half a Tylenol PM before boarding followed by one drink after takeoff; like pstm91, I'll power through the arrival day (with the help of early hotel check-in, a quick shower, a change of clothes, and an iced coffee with lunch), have a light dinner, turn in ~8pm Eastern, and set an alarm for ~6am