Look, our first trip to Hawaii was "let's do as much as possible, because who knows if we ever come back, it's a 20 hours flight". Well, we came back 2 other times and when pandemics ends, we'd come back again. So, never say never.
I would do one part of Italy, but well done. For example Tuscany (no fiorentina well-done though). Apart from visiting Florence, Siena, Lucca, there is all the topic of wines and good food. Just relaxing aroung Chianti, Val d'Orcia, drinking great red wines and eating pecorino di Pienza. There is sea coast as well.
If you do not wish to rent a car and it might be a price issue this year. I would do Rome, Naples and Florence. Easily moving around by train. Amalfi coast can be done with local buses as well. Car is more handy, but parking is a huge problem, especially in high season. Somebody rents a scooter, but local folks are very dangerous when driving.