This is really hard to say. I do not really do regular MS for income. Mainly work to get to certain elite status. So my volume is much smaller than yours. A lot of high rollers do $100k+/month.
If you pull funds from CC banks and CC banks see regular US banks and CUs, then all should be good. Same goes to pay from your own banks or CUs. But I would control the payments to fewer than 5 payments each month and each one is between $1k to $5k. I do not want to send one large payment each month either.
Also, I do not use important CCs for any MS activities. Only fringe CCs. Those CC banks do not shut down CCs often, and if they do, I do not really care. I still have the Avianca Vuela card. It earns 2 miles at grocery. I do not care if they shut me down....