A full fare F ticket for a 14,000 rt itn (via the accelerator) would earn 14000 x 2.0 x 1.75 = 49,000 MQM making a big dent in the MQM requirement. Any previously rolled over MQM are already in the MQM bank. Purchasing that trip with the appropriate AMEX card would be part of the $250,000 spend.
Sounds like an expensive ticket that would put a big dent in the MQD requirement.