Other than receiving a CDC informational card (when coming into the US), some Covid-related signs at ORD, seeing people wearing masks, and lots of lounges and retailers at the airport being closed or having way less hours than usual, my recent uses of ORD have it as almost like normal except with way less traffic than back in say January and February. With regard to CBP and the rest of the feds, not a spoken word about mandatory self-isolation, and the written verbiage was in the language of a recommendation unless local rules for the traveler had it otherwise.
For my international arrival into ORD this month, smooth as could be.