A FlyerTalk Posting Legend
Join Date: Sep 2012
Location: SFO
Programs: AC SE MM, BA Gold, SQ Silver, Bonvoy Tit LTG, Hyatt Glob, HH Diamond
Posts: 44,342
Not being able to check through an overnight is pretty common.
So is not being able to check through connections exceeding some time limit that is likely less than 12 hours.
I'd say the only unreasonable thing is expecting to manage 7 bags weighing over 350 pounds if you both require wheelchair assistance.
There are so many things that can disrupt travel and force overnight connections where you may be forced to collect and manage your luggage. If you are not capable of doing that, you should be shipping it, not traveling with it.