The thing is, getting to the Simplon pass is already a hell of a drive. The Centovalli by road is truly tiring. The other way is up and over the Nufenen, coming down the Gomstal after.
Sorry, my post above referred to the LUG-SIR and vv flights, not LUG-ZRH (I've corrected it now). That was a great trip. Only, we didn't see a single thing, it was bad weather all the way.
I think there is a good case for a LUG-GVA flight connection.