What are your goals for card(s) you acquire?
For instance, is there a particular airline or hotel chain that you favor?
Do you prefer maximum flexibility for points usage?
There are other things to consider, but I think you get the general idea.
For me, flexibility and relative ease of earning makes the Chase Ultimate Rewards program the best, but there are plenty of folks that feel otherwise. In other words, YMMV.
I have the Chase Sapphire Reserve and I like it a great deal. We spend a fair bit on travel and dining and it works well for me. I also have the Ink Plus (no longer available) and it’s a great combination.