Late to the conversation and shooting for the moon, I'd like SCE-JFK, or SCE-LGA at worst.
Living in a small town we have limited selection and it would be nice to get a flight to NYC to have easier access to the lower fares to Europe. Before the economic crisis we had a 2x daily ATL as well as DTW but now we only get ATL on the weekends in the summer. We have UA to ORD/IAD and soon AA to ORD/PHL as well as DL to DTW but that's it. Maybe AA will test a CLT flight over the summer to compete with the ATL flight?
For the most part, I don't really mind connecting at DTW and it works well for most of my flights to the west coast, I'd just prefer to get a cheaper fare to Europe without having to drive four hours to the city.