I had seat 1B on a redeye flight once (it wasn't an A321) and I wasn't very comfortable trying to sleep. I did manage to sort of angle towards the galley (my wife was in 1A) but it was a fitful nap. I think I would consider 1A (window with no chance of stretching into the aisle) to be worse than an MCE seat.

I'd rather have 2B because even with 1B is reclining "into you", it doesn't feel as bad once I'm also reclined, and I like being able to stretch out to sleep.