Previous poster precisely said he did not use Nexus because he used the OSS thing. Which indeed does not take nexus.My experience has been the opposite though, often a long line at OSS so not worth it if you have nexus, better go through the normal exit using nexus, and go through security again on the domestic side. But I guess it all depends upon the time of the day and how busy OSS is.Anyway, none of this is related to the OP's issue. But yes, I would go for the quick connection. Why give up without trying, when once you are in, it is the responsibility of the airline to bring you to destination, and rebook if needed?