Originally Posted by runderwo

After 5 years, a reapplication, another ombudsman rejection, a FOIA response pretending that a file to which the ombudsman's office referred in their rejection did not exist, and a FOIA appeal that demonstrated the government was lying about the nonexistence of the file in the FOIA response, I now have the answer.

Admission of any previous marijuana use, even though it is currently legal where I live, will disqualify you for life from Global Entry under the "strict program requirements" banner.

If the officer asks you this question, you are officially screwed because to obtain Global Entry you would be forced to make a false statement to a federal agent. The questions they choose to ask you seem to be at their discretion, so, perhaps cutting your hair and wearing a suit to your interview like it's still the 1950s would be a safe bet.