Absolutely worth the 12-hour-each-way drive from New York City to just south of Spartanburg for 2 minutes of totality (the clouds came in 5 minutes later; whew!). No eclipse-related traffic delays at all either before or after; in fact, we wondered where everyone was. Watched it in a cemetery joined by 3 other cars.
It might be "once in a lifetime" in that I don't know if I'd make the same effort again, having done it once, but I'm sure glad I did it once.
Seth