The one on Avenida Paulista near the Trianon park is the MASP, pretty good for getting an idea of Brazilian artists like Portinari if you never covered them in your college art history class.
Their other pieces are second tier (IMO) works by internationally famous artists. If you've been to museums in NYC or Europe, you might be disappointed, as I was, what with the hype about "the finest museum in SA"..

There is also the Pinacoteca, with more contemporary works.
http://www.pinacoteca.org.br/pinacoteca-en/

There is also the Lasar Segall museum, a house museum with his own works.
https://en.wikipedia.org/wiki/Museu_Lasar_Segall
His works are also in the collection of MOMA in NYC.

If you are in SP at a certain time of a certain year, you could visit the Biennial.
http://www.biennialfoundation.org/bi...olo-biennialv/

For crafts, you could take a daytrip to Embu.

That should be a start for you.
There is a pretty busy contemporary gallery and atelier scene, but it is harder and more time consuming to find.

Here is a portrait of Mario de Andrade by Anna Malfatti whose works you can find at MASP iirc.
https://obrasanitamalfatti.files.wor...ticular-sp.jpg