If you're going to Macchu Picchu - Be aware that Cuzco is VERY high altitude - between 11,000 and 11,500 feet. I had a tough time with that in Cuzco, because I use a CPAP machine, and most CPAP machines don't function very well at all above around 8000-9000 feet. I didn't know this before my trip, so I ended up booking 3 days in Cuzco first before Macchu Picchu, which turned out to be a big mistake, and I basically spent those 3 days both sleep deprived and with altitude sickness.
Thankfully, Aguas Calientes - the base village for Maccu Picchu, is actually much lower, slightly under 7000 feet - so I was able to recover prior to going to Macchu Picchu itself.
If you are interested in wine touring in Mendoza, Argentina, I can give you LOTS of detailed info. But I won't bore you with it if that's not a major interest for you.