I don't know what the availability in the US is, but I swear by my Karrimor Airport bag (there's a range of them). It's got good comparments and organisers, looks smart, and has a laptop pouch inside. It expands so that it can serve any function from laptop bag to 5-day away bag. At its fullest, it will still pass almost all airlines' carry-on regulations. You can use a hand-hold or choice of shoulder straps (which all fold away). I've had it a year, it flies weekly, gets abused, and there's not even a thread loose. I would not hesitate to recommend this to anyone.