Should I lock my check-in item?
http://www.tsa.gov/public/display?theme=87&content=527
TSA suggests that you help prevent the need to break your locks by keeping your bag unlocked
In some cases screeners will have to open your baggage as part of the screening process. If your bag is unlocked then TSA will simply open the bag and screen the bag. However if the bag is locked and TSA needs to open your bag then locks may have to be broken. You may keep your bag locked if you choose but TSA is not liable for damage caused to locked bags that must be opened for security purposes.