The late PSA Airline, primarily an intra California carrier, ordered (I believe) 2 L-1011-50s that were configured with the downstairs lounge. By the time they took delivery, PSA realized that frequency was more important than equipment on the SFO-LAX trunk route.

As for cargo, airlines like LH and BR seem to love the operational advantages of the the 747-400 combi, where cargo is stacked below and behind the main passenger cabin.

But I agree, more lavs - bigger lavs - would be a plus anywhere on the airplane!