Last year, I tried not to unpack my luggage (only one - I spend approx 90 nights outside per year, plus some others for vacations), but I discovered that each morning, before leaving, anyway, I had to unpack.
So, now, all go outside of the luggage in the minute I am in my 'new' room.

I use to put the key on the floor just in front of the door, as soon as i am inside the room. And I add similarly all the things I need not to forget.

I try alo to put in th lugage all the things that I used to loss in the hotels before, and it works pretty well too.