I open the door, turn on the light, and prop the door open with my bags while I check to make sure there isn't an unexpected "guest" waiting for me inside. (Hasn't happened, but a friend wasn't so lucky --- fortunately it only cost her purse - it could have been much, much worse).
After closing the door, I check to make sure the heat/AC work to my satisfaction so I can return to the front desk without re-packing. Ditto for other room amenities (lights, phone, and especially SHOWER - I once found out the morning after check-in that the water came out of the showerhead in a trickle and there was no plug to take a bath!)
I then check out the telephone access issue - where will I be hooking up my laptop to the phone line?
As for the unpacking, if I am in a hotel for more than 1 night, all the clean clothes come out and get put away. Dirty clothes are folded and packed. That way my final night involves packing 1 day's clothes.
I usually sleep with the drapes open - ambient light doesn't bother me. And noise isn't a big issue for me either (I once fell asleep at a local nightclub while a friend's speed-metal band was playing).
If I have to leave without taking my laptop with me, I always make sure the TV is on (ESPN, CNN), and while closing the door feign a conversation with a non-existant male roommate. "Mike, turn to the game on ESPN - I'll be back in a minute."
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"I will not be pushed, filed, stamped, indexed, briefed, debriefed or numbered. My life is my own."