sdsearch

Traveling from where? You seem to missing a couple points:

1. There is no such thing as spring in SF. It pretty much never freezes in SF, so SF doesn't have conventional four seasons there like you do back east (or even in the mountains of the west).

2. Where are you based? Many pollens, even when present, are completely different in different parts of the country. I had a bad pollen allergy every spring related to specific flowering plants while growing up in Northern Virginia. The moment I moved cross-country to Southern California, the allergies instantly vanished, because those plants don't live in this completely different climate, and I was not allergic to any Southern California plants.

Having said all that, if you're still concerned, good air conditioning that's been well maintained, in a room where windows are well sealed, will be the most important in a hotel room. Be aware that some (low-cost?) hotels in the SF area may not have air conditioning at all, because of it being a very mild climate.