You can find bed bugs in a clean suite at The Peninsula or a cheap room at Motel 6. These creatures don't discriminate between clean and dirty conditions. Just awful. They can live for months between feedings and they scatter/run quickly. It's possible to check into a room, unzip your bag on the carpet and they can jump in for a ride.
After a few incidents, I keep my luggage closed at all times, all pockets zipped. Dirty clothes go in a plastic bag and straight into washing machine. I don't put unworn undergarments back into drawer either. When I get home, I unpack in garage.
I know that even with all these precautions I can still get them (airplane seat), but the key is to isolate and the moment there's a sign, to immediately eradicate.
http://www.webmd.com/skin-problems-a...gs-infestation