Omg. So many posts. I am both a doctor and avid Africa traveler. I lived in SouthAfrica 3 years and practiced at a huge KZN hospital. I saw the grand total of one child with malaria from Mozambique. No one else. Been to Kruger multiple times as well as Zambia, Zim and the Namibia/ Angolan border and the SA/Mozambique border. Never taken anything. I'm much more afraid of viral diseases I can't treat like dengue. Malaria is easy to treat. South Africans never take anything when they travel.
The worse advice comes from USA docs. I snicker when the advice is to consult your own physician. Trust me, they know absolutely nothing and just read the CDC website. I have traveled to many nasty places. Maybe I am just lucky but I never get sick.