I won't apply for business cards, as I don't have a business and I won't lie on a credit card application.
No mileage runs or mattress runs, as I don't have the time. (Although I do foresee more weekend trips to Chicago in the future as my parents get older.)
I have no problem with the VR/BB trick as long as it's used to pay actual bills, but it's simply too much hassle and too time-consuming for me to do right now.
I won't do manufactured spend.
Since I'm not on Facebook, I won't be liking anyone there to get miles.
I will do surveys, but only if they don't take too much time. Ditto with games.
Mostly I'm content with getting my miles and points through credit card spend plus flying and hotel stays. It works for me for now!