which amex card you have? PRG is good for 3x on travel and 2x on gas/groceries so you can rack good points if you want MR points.
I also second sapphire pref. card as you can get 2x for travel/resturants...if you combine it with an ink card, freedome...you can rack some points but as many said its a marathon not a sprint on this hobby. it also depends on what you want to get out of the card..what goals you have in mind?