I am in the habit of maximizing miles only when I fly for work each week.
I would never do a MR on my off day or weekend. Just not my cup of tea. I can accumulate during the week pretty easy. I always tack on useless connections to get to my customer sites each week when I can, with 500 mile minimums, it's easy.

Example, I live south of SNA but working in SAT for a 6 months. CLD is pretty close with cheaper parking and 500 mile min per flight. I can fly SNA with one connection or LAX to SAT non stop via UA and return the same way, cost $1100 approx. Instead I fly CLD>LAX>ORD>SAT early Sunday and return SAT>ORD>LAX>CLD later in week approx. same price with approx. 6500 miles RT per week. If costs is more then I will pick cheapest RT with most miles regardless.

Anyone else doing this kind of MR during the week? Customer doesn't care as long as airfare is cheaper.