Two terrible things have happened to me. Both while flying with my daughter.
On her first flight, ORD-LAS, we were inexperienced with children. We put her in a swim diaper figuring it would keep more moisture in. Wrong. I changed out of my pants in the lav and hope to never do so again. It was close quarters. Funny in retrospect.
On my most recent flight with my daughter, LGA-ORD, she vomited on descent. Luckily very little got on anyone. Just the seats and her clothes. I've never seen a taxi take so long. Or deboarding. Or the walk of shame to the nearest bathroom where I changed her clothes. Just awful. I apologized to the flight attendants, but no apology is enough for that.