Hey Dave,
@mommypoints alluded to this above, but definitely look at the categories of your monthly spend. Outside of meeting minimum spends for bonuses, regular everyday sorts of transaction, categories will get you some decent multipliers.

For instance if you spend $30K a year an airline travel, I might call you crazy not to get the Amex PRG. Different cards multiply your category, gas, groceries, office supplies, travel, airfare, all bonuses differ by card. If you have a large spend category, look for a card that will match up (so long as it gives you a bonus you can use for your trips!).