Thanks for your responses, this has been very helpful. Since this is pretty vague and there are so many options, I will give you a little more insight into my situation and hopefully that will help with some responses.

I currently have the following cards:
SPG Amex
SPG Business Amex
Citi Hilton Honors Visa
Chase Marriott Rewards Visa

I have my own company and charge everything I can for the business. So I am typically charging about $15k-$20k per month on my AMEX and just use the other ones when someone does not take AMEX. As a result, I have over 400,000 SPG points right now. I have just been stockpiling these without much of a plan over the last 1.5 years.

Now I want to start making the best use of my points and hope to travel to China, Hawaii and the Caribbean in the next 2 years.

I don't have any airline cards and really don't have many points in any airline program. I guess I should try and find a good one to get into so that I can get some miles.

I appreciate any other suggestions anyone has.

Dave