It all depends on the kind of items and the kind of bag you are using. There is good info on that in the stickies in this forum.

Things like knits (t's, underwear, socks) can be rolled quickly and easily without risking wrinkles. They can then be stored in a packing cube, where they are easy to retrieve and don't clutter the suitcase. The packing cube should be packed so tightly that it compresses the items. Otherwise it will add only organization but at the expense of weight and space. The idea behind a packing cube is to help with organization AND volume. This is best done when it is packed in a way that the items are compressed. For compressing the items rolling them is good.

Rolling pants and shirts on the other hand is counterproductive. They will rather take up more volume and be more creased.

Till