Earplugs and eyeshade
Drugs, earplugs/ipod, eyeshade, warm slippers, warm blanket, neck pillow, chapstick. Try to get a little nap before the trip, get a little nap on the plane, then take a *little* nap when you get there. Between all those little naps, you're not so very exhausted, but ready for a good night's sleep when the night finally comes at your destination.