We did the drive last week. Actually, we drove from Bar Harbor to Campobello Island. The drive was easy. It took maybe 2 3/4 hours because we stopped for 15 minutes in Machias. We stayed overnight in Lubec. On the way back, we stopped at the Schoodic peninsula to hike around that part of Acadia. Just breathtaking!
Didn't drive in fog nor were we stuck behind trucks. We could go 50-55 mph for most of the drive unless we were driving through towns. Not that many towns actually.