Thanks for the update. To each his own, but I really do think you are missing out on a lot of Alaska by basing yourself in Anchorage for 4 nights. There is just not enough a days' drive from Anchorage to keep you busy for that long unless you love cities, museums, traffic, and shopping. Or you will end up with long travel days to somewhere and back the same day. It is a common mistake for first-timers to Alaska unfortunately.
And I travel around Southcentral Alaska a lot and rarely pack and unpack, and certainly not every day. I leave my suitcase in the car and I just pull out the few things I will need for the night and put them in my daypack. The only time my suitcase comes into the hotel is for major repacking or when I do laundry.
I have to echo FTI's advice on this one, understanding that it is your trip and your travel plans. Also keep in mind that Alaska is pretty fast and if you stay planted in Anchorage, you will potentially have a lot of windshield time getting to the places you may be so inclined to take in.
Our first trip to Alaska back in 2006 we made that choice as well, and ran ourselved ragged on the three or four days we had available to see and to things. We did a wildlife/whale tour out of Whittier, a "day trip" to Seward and Kenai Fjords NP (Exit Glacier) and a fishing charter out of Soldotna. LORD, knowing what I know now about travel in Alaska and my more recent trip planning, I'm tired just typing that.
Perhaps you will plan to do more localized stuff in and around Anchorage, so it won't be a big deal to you.