Originally Posted by
mlshanks
I'd discard jackal's idea of taking a Metrolink train for part of the route.... The stops (Van Nuys & Northridge) don't interface well with the bus routes you'll need to get to Granada Hills and the schedules are all commuter oriented (and don't run weekends).
The combination Metrolink/bus options don't really save any time over the straight bus options, but they do exist (and come up on Google Transit searches) and take about the same amount of time (1 hour total), so they are an option should it be the only thing workable time-wise. All other things being equal, though, straight bus options from BUR (nothing direct, AFAIK--they all do require transfers) are the cheapest and most frequent.
The combination Metrolink/cab option may be the fastest and most convenient (if the times work), but like I said, at that point, you're better off just flying into LAX and taking a cab from the Van Nuys FlyAway depot.