Boooooooooooooooo!
I tried it. Until I see something radically different, it was the first and last time I'll be doing so. The inability to search multiple origin and destination airports is a total deal breaker -- if I just want to do a point-to-point search in a nice GUI and with slider bars for parameters, I will use Kayak and it will be a lot faster. The appeal of ITA has always been that it allowed superusers to really go to town with complex query language and multiple airports in the to/from fields.
This is a total flop so far and doesn't even replicate what other sites already do better. Here's to hoping that Matrix 1 isn't replaced by this -- I'd never have a reason to use it as a tool again.
peace,
~Ben~