I have never missed a flight of my own volition/control/etc., but I got IIROP'd into something quite odd. Thanksgiving freakish storms in Florida, supposed to fly home PBI-EWR. Inbound flight gets rerouted to FLL. Drive to FLL instead of PBI. Delays cascaded to the point that we were going to stop in JAX to pick people up. K, fine. Finally get to JAX, and as we're taxiing in, pilot says "Ladies and Gentlemen, for those of you that were connecting here to make your flight home to Newark, if you look out the right side of the aircraft, you will see the plane that you're supposed to be on."

Forced layover in JAX, and on top of that we have to go to MSY. Fly JAX-MSY, and then finally MSY-EWR. Phew.