Very easy - Cambie or Granville south to SW Marine Dr. and the Oak St. Bridge/BC 99 - all the way to the border. Note there are two crossings, the main freeway one at the Peace Arch, or the "truck" or "Pacific Highway" crossing a little east. There may or may not be much difference in wait times; several local radio stations in Vancouver have frequent border delay segments in their broadcasts. One thing to note is that there are no public loos anywhere near the Pacific Hwy crossing, so if the lineup is long....