Order of Itinerary
 

Tentative itinerary for my next trip in November...into Amsterdam, then Brussels, Paris, Annecy, fly back from Geneva. Any advantages or disadvantages to doing it in reverse? (Just working on flights and deciding what makes the most sense, or if it doesn’t really matter.)

Same price? If not, it does matter! If yes, it doesn't... :)

Not significantly different but I’m going to crunch the numbers again and make sure.

Apart from the price, the departing airport could be a reason. But I do not know what type of traveller you are. Personally if I were the "early at the airport" type of person I'd prefer AMS; for getting through quickly, GVA.
If flying Star Alliance, GVA; for Sky Team... (you get the picture).

And are you looking forward to snow in Annecy/Genève, or wanting to avoid it? (In case your trip takes a few weeks...)