Another challenge with staying DT is that parking will be very expensive - parking rates at some of the downtown 4* hotels that are commonly won on Priceline and Hotwire are upwards of $50 per night
Also, although
SkiAdcock is spot-on with her assessment of the lack of DT LA nightlife, since you are an Entoruage fan, you might enjoy knowing that in the Season Three episode in which Turtle and Drama go looking for the mising rapper Saigon, the hotel where they eventually find him (and where Drama almost gets thrown into the pool) is the Hotel Standard, a bit of a party-place located in the very center of Downtown.