Depends on where you're traveling. If business/leisure takes you to the west coast, United offers nonstops to DEN/SFO/LAX.
AirTran also has a big presence there, flying to: Atlanta, Boston, Burlington (VT), Charlotte, Dallas/Fort Worth [seasonal], Dayton, Fort Lauderdale, Fort Myers, Los Angeles [seasonal], Miami [seasonal], Milwaukee, Orlando, Portland (ME), Rochester (NY), San Juan [begins December 20], Sarasota/Brandenton, Seattle/Tacoma [seasonal], Tampa, West Palm Beach [seasonal].
Southwest destinations:
Albany, Albuquerque, Austin, Birmingham (AL), Buffalo, Chicago-Midway, Cleveland, Columbus (OH), Denver, Detroit, Fort Lauderdale, Fort Myers, Hartford, Houston-Hobby, Indianapolis, Jackson, Jacksonville, Kansas City, Las Vegas, Little Rock, Long Island/Islip, Louisville, Manchester (NH), Nashville, New Orleans, Norfolk, Oklahoma City, Orlando, Phoenix, Pittsburgh, Providence, Raleigh/Durham, St. Louis, Salt Lake City, San Antonio, San Diego, Tampa, West Palm Beach