It could make sense.

I use Fedex for a lot of my trips. For several years I carried 5-8 notebook computers on board. But it was a lot of hassle, and plane side check in is risky on RJs. Early this year I picked up a big Pelican case (model 1630) and just stick my equipment in there.

The equipment is better protected, it doesn't get scratched up, and it's a heck of a lot less hassle at the airport. Stuff is less likely to get stolen when I'm not looking, and if anything goes wrong, it's insured.

Most hotels handle Fedex with no problem, though when I leave, I usually just bring the beast to a Fedex Kinkos and drop it off there. That way I know it gets scanned into the Fedex system and I can track.

Shipping costs do add up, but then again, this beast is 75 pounds.

If this is something you will do on a regular basis, you may want to look for something optimized for shipping, rather than luggage.