I use a MXI Stealth MXP with a biometric reader.

http://www.mxisecurity.com/?p=produc...lth_mxp_family

Pros: AES 256 Bit encryption in hardware, industrial biometric reader, tamper resistant, driverless, works with Windows, Mac, Linux, etc. Can also be used as an authentication factor/tool.

Con: expensive

A simple software based soluition is good enough for most folks. Depends on how bad you want to keep the data encrypted and the standards/requirements you must comply with...