Why would anyone feel the need to take on responsibility for a stranger without even knowing if the stranger wants them to? If a seatmate asked to have the FA wake them or, or not wake them up, I'd be happy to comply. If they don't say anything one way or another, then I allow nature to take its course. I would never presume to make the choice for them on whether they might want to be awakened or not as psychic abilities are not one of my strong points.
For me, when flying alone I tend to leave things to random chance and 99 percent of the time the FA does not wake me up. With hubby on a long haul, he gives this disclaimer: "YOU can try if you want, but I sure as heck ain't gonna do it!" (I am not a pleasant sort when stirred from a sound sleep.)